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Literature summary for 3.4.21.75 extracted from

  • Susan-Resiga, D.; Essalmani, R.; Hamelin, J.; Asselin, M.C.; Benjannet, S.; Chamberland, A.; Day, R.; Szumska, D.; Constam, D.; Bhattacharya, S.; Prat, A.; Seidah, N.G.
    Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10 (2011), J. Biol. Chem., 286, 22785-22794.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
 DSSARIRRNAKG pH 7.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
intracellular
-
 Homo sapiens 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DSSARIRRNAKG + H2O Homo sapiens peptide derived bone morphogenetic protein BMP10, cleavage occurs at residue R316 DSSARIRR + NAKG
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DSSARIRRNAKG + H2O peptide derived bone morphogenetic protein BMP10, cleavage occurs at residue R316 Homo sapiens DSSARIRR + NAKG
-
 ?
DSSARIRRNAKG + H2O peptide-derived bone morphogenetic protein BMP10, cleavage occurs at residue R316 Homo sapiens DSSARIRR + NAKG
-
 ?

General Information

General Information Comment Organism
physiological function furin is involved in processing of bone morphogenetic protein BMP10. Processing occurs mostly intracellularly, but also at the cell surface Homo sapiens