Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of furin expression by siRNA significantly inhibits invasion and migration of HTR8/SVneo cells, with corresponding decrease of matrix metalloproteinase-9, MMP-9, activities. In contrast, overexpression of furin markedly increases cell invasion and migration, accompanied by significant increase of MMP-9 activities. Furthermore, furin siRNA significantly increases the levels of both tissue inhibitors of MMPs, TIMP-1 and -2, overview. Proliferation of HTR8/SVneo cells is inhibited by furin siRNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HTR-8/SVneo cell | extravillous cells | Homo sapiens | - |
additional information | furin is ubiquitously expressed | Homo sapiens | - |
placenta | furin is highly expressed in placental villi during early pregnancy, specifically in trophoblast column and trophoblast shell, regions where highly invasive cytotrophoblast cells invade the maternal decidua during human placentation | Homo sapiens | - |
trophoblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Proprotein convertase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | furin is involved in many physiological and pathological processes | Homo sapiens |
physiological function | furin is involved in many physiological and pathological processes, it plays a role in human trophoblast invasion and migration | Homo sapiens |