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Literature summary for 3.4.21.75 extracted from

  • Zhou, Z.; Shen, T.; Zhang, B.H.; Lv, X.Y.; Lin, H.Y.; Zhu, C.; Xue, L.Q.; Wang, H.
    The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion (2009), Placenta, 30, 929-938.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information knockdown of furin expression by siRNA significantly inhibits invasion and migration of HTR8/SVneo cells, with corresponding decrease of matrix metalloproteinase-9, MMP-9, activities. In contrast, overexpression of furin markedly increases cell invasion and migration, accompanied by significant increase of MMP-9 activities. Furthermore, furin siRNA significantly increases the levels of both tissue inhibitors of MMPs, TIMP-1 and -2, overview. Proliferation of HTR8/SVneo cells is inhibited by furin siRNA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HTR-8/SVneo cell extravillous cells Homo sapiens
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additional information furin is ubiquitously expressed Homo sapiens
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placenta furin is highly expressed in placental villi during early pregnancy, specifically in trophoblast column and trophoblast shell, regions where highly invasive cytotrophoblast cells invade the maternal decidua during human placentation Homo sapiens
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trophoblast
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Homo sapiens
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Synonyms

Synonyms Comment Organism
Proprotein convertase
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Homo sapiens

General Information

General Information Comment Organism
malfunction furin is involved in many physiological and pathological processes Homo sapiens
physiological function furin is involved in many physiological and pathological processes, it plays a role in human trophoblast invasion and migration Homo sapiens