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Literature summary for 3.4.21.75 extracted from

  • Hagiwara, S.; Murakumo, Y.; Mii, S.; Shigetomi, T.; Yamamoto, N.; Furue, H.; Ueda, M.; Takahashi, M.
    Processing of CD109 by furin and its role in the regulation of TGF-beta signaling (2010), Oncogene, 29, 2181-2191.
    View publication on PubMed
Search for more literature for 3.4.21.75

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
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plasma membrane
-
 Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-CD109 + H2O Homo sapiens CD109 is produced as a 205 kDa glycoprotein, which is then processed in the Golgi apparatus into 180 kDa and 25 kDa proteins by furin CD109 + CD109 propeptide
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-CD109 + H2O CD109 is produced as a 205 kDa glycoprotein, which is then processed in the Golgi apparatus into 180 kDa and 25 kDa proteins by furin Homo sapiens CD109 + CD109 propeptide
-
 ?
pro-CD109 + H2O CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, cleavage motif comprises amino acids 1270-RRRR-1273 Homo sapiens CD109 + CD109 propeptide
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 ?

Synonyms

Synonyms Comment Organism
furinase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function furin cleavage of CD109 is necessary for its biological activity, CD109 negatively regulates transforming growth factor-beta signaling in keratinocytes by directly modulating receptor activity. Processing of CD109 into 180 kDa and 25kDa proteins by furin, followed by complex formation with the type I TGF-beta receptor is required for the regulation of TGF-beta signaling in cancer cells and keratinocytes Homo sapiens