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Literature summary for 3.4.21.75 extracted from

  • Cousin, C.; Bracquart, D.; Contrepas, A.; Corvol, P.; Muller, L.; Nguyen, G.
    Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma (2009), Hypertension, 53, 1077-1082.
    View publication on PubMed
Search for more literature for 3.4.21.75

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin Portland variant i.e. alpha1-PDX, inhibits furin and the generation of soluble (pro)renin receptor Homo sapiens
alpha1-antitrypsin Portland variant i.e. alpha1-PDX, inhibits furin and the generation of soluble (pro)renin receptor Mus musculus
alpha1-antitrypsin Portland variant i.e. alpha1-PDX, inhibits furin and the generation of soluble (pro)renin receptor Rattus norvegicus
additional information no inhibition by metalloprotease inhibitor GM6001 Homo sapiens
additional information no inhibition by metalloprotease inhibitor GM6001 Mus musculus
additional information no inhibition by metalloprotease inhibitor GM6001 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Mus musculus 5794
-
Golgi apparatus
-
 Homo sapiens 5794
-
Golgi apparatus
-
 Rattus norvegicus 5794
-
intracellular
-
 Mus musculus 5622
-
intracellular
-
 Homo sapiens 5622
-
intracellular
-
 Rattus norvegicus 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
full-length (pro)renin receptor + H2O Mus musculus i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O Homo sapiens i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O Rattus norvegicus i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ES-E14 cell
-
 Mus musculus
-
glomerular epithelial cell
-
 Mus musculus
-
glomerular epithelial cell
-
 Homo sapiens
-
additional information colorectal carcinoma LoVo cell line is devoid of furin activity Homo sapiens
-
RST-307 cell
-
 Mus musculus
-
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
full-length (pro)renin receptor + H2O i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma Mus musculus soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma Homo sapiens soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O i.e. (P)RR, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A. The soluble form of the (pro)renin receptor generated through intracellular cleavage by furin is secreted in plasma Rattus norvegicus soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O i.e. (P)RR, a 35 kDa protein, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A Mus musculus soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O i.e. (P)RR, a 35 kDa protein, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A Homo sapiens soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?
full-length (pro)renin receptor + H2O i.e. (P)RR, a 35 kDa protein, cleavage site at Arg275-X-X-Arg278-/-, no activity with (P)RR mutant R275A/KT/R278A Rattus norvegicus soluble (pro)renin receptor + 10 kDa fragment of (pro)renin receptor i.e. s(P)RR, a 28 kDa protein ?

General Information

General Information Comment Organism
physiological function furin is responsible for the shedding of the endogenous (pro)renin receptor, (P)RR, it generates the soluble form of (P)RR, in cultured cells Mus musculus
physiological function furin is responsible for the shedding of the endogenous (pro)renin receptor, (P)RR, it generates the soluble form of (P)RR, in cultured cells Homo sapiens
physiological function furin is responsible for the shedding of the endogenous (pro)renin receptor, (P)RR, it generates the soluble form of (P)RR, in cultured cells Rattus norvegicus