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Literature summary for 3.4.21.75 extracted from
- Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain (2010), Curr. Med. Chem., 17, 2214-2221.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| decanoyl-RVRR-chloromethyl ketone | - |
Homo sapiens |  |
| hfurin25-107 | i.e. furin prodomain protein, competitive inhibitor, blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain, overview. Secondary structure of furin prodomain protein, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| colonic cancer cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | furin cleavage sequence is RXXR-/-X, X is not Cys | Homo sapiens | ? | - |
? | |
| N-benzyloxycarbonyl-RVRR-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-RVRR + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | secondary structure of furin prodomain protein, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Proprotein convertase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
| 0.000156 | - |
hfurin25-107 | pH 7.4, 37°C, versus N-benzyloxycarbonyl-RVRR-4-methylcoumarin 7-amide | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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