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Literature summary for 3.4.21.75 extracted from

  • Hook, V.; Funkelstein, L.; Toneff, T.; Mosier, C.; Hwang, S.R.
    Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin (2009), Endocrine, 35, 429-437.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 x * 60000-65000, Western blot analysis, PC1/3 and PC2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pituitary gland expresses PC1/3 and PC2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
POMC prohormone precursor + H2O human pituitary may utilize the cathepsin L and prohormone convertase pathways for producing POMC-derived peptide hormones Homo sapiens ACTH + alpha-MSH + beta-endorphin
-
 ?

Synonyms

Synonyms Comment Organism
PC1/3
-
 Homo sapiens
PC2
-
 Homo sapiens
prohormone convertase 1
-
 Homo sapiens
prohormone convertase 2
-
 Homo sapiens