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Literature summary for 3.4.21.75 extracted from
- Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation (2008), EMBO J., 27, 2580-2591.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 293T cells transfected with furin | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | deletion of the cysteine-rich domain and the cytoplasmic tail of furin does not abolish binding to cripto | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Bromopalmitate | inhibits nodal processing by Flag-tagged furin | Mus musculus |  |
| brefeldin A | inhibits the secretion of furin | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cytoplasmic tail | Mus musculus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nodal + H2O | cripto interacts with the nodal pro segment and mature domain and presents uncleaved precursor to extracellular furin that is recruited through its P-domain | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Proprotein convertase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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