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Literature summary for 3.4.21.75 extracted from

  • Follis, K.E.; York, J.; Nunberg, J.H.
    Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry (2006), Virology, 350, 358-369.
    View publication on PubMed
Search for more literature for 3.4.21.75

Application

Application Comment Organism
medicine introduction of a prototypic furin recognition motif at R667 of the SARS coronavirus spike glycoprotein allows for efficient cleavage of the mutant glycoprotein and increases cell-cell fusion activity but shows no effect on virion infectivity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
furin precursor cDNA transferred to pcDNA3.1-. Co-expression of furin-site-containing spike glycoprotein with furin cDNA in FD11 cells or CHO cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information FD11 cell line, deficient in furin protease, processing of furin-site-containing glycoproteins is abrogated Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
trans-Golgi network
-
 Homo sapiens 5802
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SARS coronavirus spike glycoprotein + H2O introduction of a prototypic furin recognition motif at R667 allows for efficient cleavage of the mutant glycoprotein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
furin protease
-
 Homo sapiens