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Literature summary for 3.4.21.75 extracted from

  • Veit, G.; Zimina, E.P.; Franzke, C.W.; Kutsch, S.; Siebolds, U.; Gordon, M.K.; Bruckner-Tuderman, L.; Koch, M.
    Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment (2007), J. Biol. Chem., 282, 27424-27435.
    View publication on PubMed
Search for more literature for 3.4.21.75

Cloned(Commentary)

Cloned (Comment) Organism
furin cDNA ligated into a modified pCEP-Pu vector carrying a 5'-SPARC/BM40 signal peptide and a 3'-FLAG tag. HEK 293-EBNA cells cotransfected with full-length alpha1(XXIII) or furin cDNA and phosphatidylinositol-linked placental alkaline phosphatase or human transferrin receptor cDNA, respectively Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AEBSF partially inhibits ectodomain shedding by 45% Mus musculus
alpha1-antitrypsin
-
 Mus musculus
antipain minimal inhibition of ectodomain shedding Mus musculus
chymostatin minimal inhibition of ectodomain shedding Mus musculus
decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone efficiently inhibits ectodomain shedding by 95% Mus musculus
E-64 minimal inhibition of ectodomain shedding Mus musculus
leupeptin minimal inhibition of ectodomain shedding Mus musculus
additional information pepstatin A, 1,10-ortho-phenanthroline, EDTA, or TAPI-0 do not inhibit ectodomain shedding Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Mus musculus 5794
-
additional information localization of furin predominantly outside lipid rafts Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
membrane-bound collagen XXIII + H2O furin is the major protease to process collagen XXIII. Processing occurs after the downstream recognition motif 94KIRTVR99, releasing the ectodomain Mus musculus shed collagen XXIII
-
 ?

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 Mus musculus
sheddase
-
 Mus musculus