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Literature summary for 3.4.21.75 extracted from
- Possible role of histone H1 in the regulation of furin-dependent proprotein processing (2007), Acta Biochim. Biophys. Sin., 39, 173-180.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| furin and pro-von Willebrand factor co-expressed in BHK21 cells. cDNA of furin subcloned into the pcDNA3/VSV expression vector between the EcoRI and XbaI sites. HeLa cells transiently transfected with pCMV-furin, pCDNA3-furin-VSV or pSVHVWF1.1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| histone H1 | efficiently blocks furin-dependent pro-von Willebrand factor processing in a dose-dependent manner, interaction between histone H1 and furin mainly takes place on the cell surface. H1 may be involved in extracellular and/or intracellular furin regulation | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Proprotein convertase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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