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Literature summary for 3.4.21.75 extracted from

  • Kacprzak, M.M.; Peinado, J.R.; Than, M.E.; Appel, J.; Henrich, S.; Lipkind, G.; Houghten, R.A.; Bode, W.; Lindberg, I.
    Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine (2004), J. Biol. Chem., 279, 36788-36794.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(D-Arg)9-amide protects RAW264.7 cells against anthrax toxemia with an IC50 of 0.0037 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 pGlu-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pGlu-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000013
-
 (D-Arg)9-amide
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0037
-
 protects RAW264.7 cells against anthrax toxemia with an IC50 of 0.0037 mM Homo sapiens (D-Arg)9-amide