KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0066 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPalpha | Daboia russelii russelii | |
0.00952 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPbeta | Daboia russelii russelii | |
0.01 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPgamma | Daboia russelii russelii | |
0.0105 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPdelta | Daboia russelii russelii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Daboia russelii russelii | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
23000 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
32901 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
33363 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
38000 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
39000 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
333571 | - |
x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Daboia russelii russelii | - |
isozymes RV-FVPalpha, RV-FVPbeta, RV-FVPgamma, and RV-FVPdelta | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | sugar content of isozymes of 42-44%, overview. Partial deglycosylation under denaturing conditions by PNGase F | Daboia russelii russelii |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | Russell's viper venom | Daboia russelii russelii | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
isozyme RV-FVPa, no other protease isoenzyme, displays cytotoxicity towards MCF-7 or Colo-205 cells. 250 nM of isozyme inhibits 31.7% and 6.4% of growth of MCF-7 and Colo-205 cells, respectively, after 72 h of incubation | Daboia russelii russelii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bovine fibrinogen + H2O | the fibrinogen degradation products are separated by RP-HPLC followed by mass spectrometric analysis | Daboia russelii russelii | ? | - |
? | |
Bovine serum albumin + H2O | - |
Daboia russelii russelii | ? | - |
? | |
casein + H2O | - |
Daboia russelii russelii | ? | - |
? | |
D-Val-Leu-Lys-4-nitroanilide + H2O | - |
Daboia russelii russelii | D-Val-Leu-Lys + 4-nitroaniline | - |
? | |
Fibrin + H2O | - |
Daboia russelii russelii | ? | - |
? | |
human plasma fibrinogen + H2O | the fibrinogen degradation products are separated by RP-HPLC followed by mass spectrometric analysis | Daboia russelii russelii | ? | - |
? | |
additional information | specific activity of these protease isoenzymes against various protein substrates, overview. No activity with bovine serum globulin and azocasein | Daboia russelii russelii | ? | - |
? | |
N-benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide + H2O | - |
Daboia russelii russelii | N-benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline | - |
? | |
N-benzoyl-Phe-Val-Arg-4-nitroanilide + H2O | - |
Daboia russelii russelii | N-benzoyl-Phe-Val-Arg + 4-nitroaniline | - |
? | |
Nalpha-benzoyl-L-Arg-4-nitroanilide + H2O | - |
Daboia russelii russelii | Nalpha-benzoyl-L-Arg + 4-nitroaniline | - |
? | |
Nalpha-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O | - |
Daboia russelii russelii | Nalpha-tosyl-Gly-Pro-Arg + 4-nitrolaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 23000, about , deglycosylated isozymes, SDS-PAGE, x * 38000, isozyme RV-FVPalpha, SDS-PAGE, x * 39000, isozyme RV-FVPbeta and isozyme RV-FVPgamma, SDS-PAGE, x* 40000, isozyme RV-FVPdelta, SDS-PAGE, x * 32901, isozyme RV-FVPalpha, mass spectrometry, x * 33363, isozyme RV-FVPbeta, mass spectrometry, x * 333571, isozyme RV-FVPgamma, mass spectrometry, x* 34594, isozyme RV-FVPdelta, mass spectrometry | Daboia russelii russelii |
Synonyms | Comment | Organism |
---|---|---|
RVV protease | - |
Daboia russelii russelii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Daboia russelii russelii |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPdelta | Daboia russelii russelii | |
0.33 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPbeta | Daboia russelii russelii | |
0.34 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPgamma | Daboia russelii russelii | |
1.042 | - |
human plasma fibrinogen | pH 7.4, 37°C, isozyme RV-FVPalpha | Daboia russelii russelii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Daboia russelii russelii |