Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00749 | - |
- |
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Mus musculus |
uPA | - |
Homo sapiens |
Urokinase-type plasminogen activator | - |
Mus musculus |
Urokinase-type plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme receptor defciient mice show no lipid droplets in their livers compared to wild-type C57BL/6 mice and the triglyceride levels are significantly lower, phenotype, overview | Mus musculus |
physiological function | the urokinase-type plasminogen activator regulates gene expression in the liver involving peroxisome-proliferator-activated receptor gamma's transcriptional activity and stimulates triglyceride synthesis in Huh-7 hepatoma cells via p38-dependent upregulation of diglyceride acyltransferase 2. Also, the amount of free fatty acids is highly up regulated by the enzyme through activation of the transcription factor SREBP-1., overview | Homo sapiens |