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Literature summary for 3.4.21.73 extracted from

  • Farris, S.D.; Hu, J.H.; Krishnan, R.; Emery, I.; Chu, T.; Du, L.; Kremen, M.; Dichek, H.L.; Gold, E.; Ramsey, S.A.; Dichek, D.A.
    Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins (2011), J. Biol. Chem., 286, 22665-22677.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
macrophage-specific uPA overexpression accelerates atherosclerosis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57BL/6
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Synonyms

Synonyms Comment Organism
uPA
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 Mus musculus
Urokinase plasminogen activator
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 Mus musculus

General Information

General Information Comment Organism
malfunction macrophage-specific uPA overexpression accelerates atherosclerosis and causes aortic root dilation in fat-fed Ldlr-/-mice. Macrophage-expressed uPA accelerates atherosclerosis by stimulation of lesion progression rather than initiation and causes disproportionate lipid accumulation in early lesions. uPA-accelerated atherosclerosis and aortic dilation are largely, if not completely, independent of uPA receptor, uPAR. In the absence of uPA overexpression, however, uPAR contributes modestly to both atherosclerosis and aortic dilation Mus musculus
physiological function the urokinase plasminogen activator/uPA receptor/plasminogen system is involved in the development of atherosclerosis and aneurysms, modeling, overview Mus musculus