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Literature summary for 3.4.21.73 extracted from
- Ab initio molecular orbital calculations on specific interactions between urokinase-type plasminogen activator and its receptor (2009), J. Mol. Graph. Model., 28, 46-53.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | complex formation of uPA and uPAR is a target for development of therapeutics | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | uPA forms a complex with its cogante receptor uPAR, specific interctions, analysis, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | uPA forms a complex with its cogante receptor uPAR, specific interctions, analysis, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | structure of uPA and uPAR complex in water and specific interactions between uPA and uPAR, analysis by classical molecular mechanics simulations and ab initio molecular orbital calculations based on fragment molecular orbital method, overview. 20-26 amino acid residues of uPA are important for the binding between uPA and uPAR, and electrostatic interactions largely contribute to the binding, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| uPA | - |
Homo sapiens |
| Urokinase-type plasminogen activator | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | binding of urokinase-type plasminogen activator, uPA, to the uPA receptor, uPAR, existing on the surface of cancer cell is considered to be a trigger for cancer invasions | Homo sapiens |
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Release 2023.1 (January 2023)
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