Literature summary for 3.4.21.73 extracted from

Zhou, H.; Tang, Y.; Liang, X.; Yang, X.; Yang, J.; Zhu, G.; Zheng, M.; Zhang, C.
RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo (2009), Int. J. Cancer, 125, 453-462.

Search for more literature for 3.4.21.73

Cloned(Commentary)

Cloned (Comment)	Organism
uPA quantitative real-time RT-PCR expression analysis in oral squamous cell carcinoma, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
oral squamous cell carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
uPA	-	Homo sapiens
Urokinase-type plasminogen activator	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	urokinase-type plasminogen activator receptor, u-PAR, is overexpressed in many human malignant tumors including oral squamous cell carcinoma and plays an important role in a variety of cancer key cellular events as a versatile signaling orchestrator. MMP-9, MMP-2 and u-PA enzymatic activities are significantly reduced in u-PAR-specific siRNA cells. RNAi targeting u-PAR can effectively inhibit the metastasis and progression of oral squamous cell carcinoma in vivo	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)