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Literature summary for 3.4.21.73 extracted from

  • Shih, Y.W.; Lee, Y.C.; Wu, P.F.; Lee, Y.B.; Chiang, T.A.
    Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase-plasminogen activator (2009), Hepatol. Res., 39, 998-1009.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
semiquantitative reverse transcription PCR expression analysis of uPA and uPAR, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Plumbagin leads to uPA inhibition and downregulation, inhibits adhesion, migration and invasion in HepG2 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O casein-plasminogen zymography assay method Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
urokinase-plasminogen activator
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens plumbagin induces the enzyme expression in Hep-G2 cells, liver carcinoma cells, also inhibiting the invasion and migration of the cancer cells, overview up

General Information

General Information Comment Organism
malfunction uPA is involved in adhesion, migration and invasion of hepatic Hep-G2 cancer cells, inhibition and downregulation of uPA by plumbagin also leads to inhibition of adhesion, migration and invasion by plumbagin in HepG2 cells, overview Homo sapiens