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Literature summary for 3.4.21.73 extracted from

  • Ports, M.O.; Nagle, R.B.; Pond, G.D.; Cress, A.E.
    Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis (2009), Cancer Res., 69, 5007-5014.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha6 integrin + H2O Homo sapiens alpha6 integrin is present on prostate carcinoma escaping the gland via nerves. Urokinase-dependent cleavage of the laminin binding domain from the prostate tumor cell surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation single chain, activated urokinase Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
PC3-B1 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha6 integrin + H2O alpha6 integrin is present on prostate carcinoma escaping the gland via nerves. Urokinase-dependent cleavage of the laminin binding domain from the prostate tumor cell surface Homo sapiens ?
-
 ?
alpha6 integrin + H2O i.e. alpha6p Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction uPA-dependent cleavage of alpha6integrin is involved in onset and progression of osseous metastases. Alpha6 integrin cleavage permits extravasation of human prostate cancer cells from circulation to bone and can be manipulated to prevent metastasis Homo sapiens