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Literature summary for 3.4.21.73 extracted from

  • Killeen, S.D.; Wang, J.H.; Andrews, E.J.; Redmond, H.P.
    Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system (2009), Br. J. Cancer, 100, 1589-1602.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Inhibitors

Inhibitors Comment Organism Structure
amiloride a selective u-PA inhibitor Homo sapiens
WXC-340 a selective u-PA inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted by cell cultures to the supernatant Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-
SW-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
u-PA
-
 Homo sapiens
uPA
-
 Homo sapiens
Urokinase plasminogen activator
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens lipopolysaccharide induces u-PA expression. TLR-4 and NF-kappaB inhibition ameliorates LPS-enhanced u-PA and u-PAR expression, tumour cell vitronectin adhesion and ECM invasion up

General Information

General Information Comment Organism
malfunction inhibition of u-PAR and u-PA attenuates lipopolysaccharid-mediated tumour cell adhesion and invasion Homo sapiens
additional information lipopolysaccharide promotes tumour cell ECM adhesion and invasion through activation of the u-PA system in a TLR-4- and NF-kappaB-dependent manner, overview Homo sapiens