Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | binding of uPA to uPA receptor increases the catalytic efficiency by enhancing its activation by plasmin or other enzymes. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of the urokinase-type plasminogen activator N-terminal fragment, uPA ATF, inhibits the combination of uPA receptor and uPA competitively, and the cell invasive migration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | activation | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | outermost epithelial cells of the hair follicle | Homo sapiens | - |
hair follicle | uPAR is overexpressed in outer root sheath and interfollicle epidermis, and expressed in the outermost epithelial cells of the hair follicle and the basal keratinocytes of epidermis, the expression decreases with the development of the hair follicle | Homo sapiens | - |
keratinocyte | basal keratinocytes of epidermis at the hair follicle. Expression of uPA and uPA receptor is selectively induced at the very tip of the leading edge of the keratinocytes | Homo sapiens | - |
additional information | uPA and uPA receptor are expressed during invasive migration of the hair follicle, not under normal circumstances. uPAR promotes the invasive migration of hair follicles synergizing in manner dependent and independent of uPA during human prenatal morphogenesis | Homo sapiens | - |
skin | basal keratinocytes of epidermis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | activation | Homo sapiens | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of uPAR promotes the invasive migration of hair follicle into the dermis in an uPA-dependent and an uPA-independent, ERK-dependent manner during human prenatal development | Homo sapiens |
physiological function | uPA is a potent catalyst of extracellular proteolysis and manifests this action through the conversion of plasminogen into plasmin, which has a range of specificities | Homo sapiens |