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Literature summary for 3.4.21.73 extracted from

  • Li, H.; Soria, C.; Griscelli, F.; Opolon, P.; Soria, J.; Yeh, P.; Legrand, C.; Vannier, J.P.; Belin, D.; Perricaudet, M.; Lu, H.
    Amino-terminal fragment of urokinase inhibits tumor cell invasion in vitro and in vivo: respective contribution of the urokinase plasminogen activator receptor-dependent or -independent pathway (2005), Hum. Gene Ther., 16, 1157-1167.
    View publication on PubMed
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Application

Application Comment Organism
medicine amino-terminal fragment ATF of urokinase exerts an antitumor effect via dual mechanisms: essentially through targeting the uPA-uPAR system via the EGF-like domain and partially through targeting a uPAR-indepedent interaction via the kringle domain Mus musculus
medicine amino-terminal fragment ATF of urokinase exerts an antitumor effect via dual mechanisms: essentially through targeting the uPA-uPAR system via the EGF-like domain and partially through targeting a uPAR-indepedent interaction via the kringle domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information humanized murine ATF, i.e. an amino-terminal fragment of urokinase, represses 79% of membrane-associated enzyme activity on MDA-MB-231 cells, murine ATF represses 29% of activity Homo sapiens
additional information humanized murine ATF, i.e. an amino-terminal fragment of urokinase, represses 29% of membrane-associated enzyme activity on LLC cells, murine ATF represses 74% of activity Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
LLC cell
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 Mus musculus
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MDA-MB-231 cell breast cancer cell Homo sapiens
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