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Literature summary for 3.4.21.73 extracted from
- Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain (1992), J. Biol. Chem., 267, 18224-18229.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
uPA from Serono and low-molecular weight uPa from Le Petit | - |
| Mammalia | - |
uPA from Serono and low-molecular weight uPa from Le Petit | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Cellular receptor of urokinase-type plasminogen activator + H2O | cleavage between domains 1 and 2 generating a cell-associated variant of the receptor of urokinase-type plasminogen activator without ligand-binding properties, uPA catalyzed cleavage does not require binding of the protease to the receptor through its epidermal growth factor-like receptor-binding domain, low-molecular weight uPA lacking this domain also cleaves the substrate | Homo sapiens | ? | - |
? |  |
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
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Release 2023.1 (January 2023)
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