Literature summary for 3.4.21.72 extracted from

Johnson, T.A.; Qiu, J.; Plaut, A.G.; Holyoak, T.
Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of Haemophilus influenzae IgA1 protease (2009), J. Mol. Biol., 389, 559-574.

Search for more literature for 3.4.21.72

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 0.1 M sodium acetate, pH 5.0, 0.1 M potassium dihydrogen phosphate and 10% (w/v) PEG 20000	Haemophilus influenzae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
108700	-	calculated from amino acid sequence	Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
immunoglobulin A1 + H2O	Haemophilus influenzae	IgA proteases only cleave the proline, serine and threonine rich hinge peptide unique to immunoglobulin A1	oligopeptides derived from immunoglobulin A1	-	?

Organism

Organism	UniProt	Comment	Textmining
Haemophilus influenzae	P44969	strain Rd 6His	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA agarose column chromatography	Haemophilus influenzae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
immunoglobulin A1 + H2O	IgA proteases only cleave the proline, serine and threonine rich hinge peptide unique to immunoglobulin A1	Haemophilus influenzae	oligopeptides derived from immunoglobulin A1	-	?

Synonyms

Synonyms	Comment	Organism
IgA1 protease	-	Haemophilus influenzae
IgAP	-	Haemophilus influenzae
immunoglobulin A1 protease	-	Haemophilus influenzae

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Release 2023.1 (January 2023)