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Literature summary for 3.4.21.72 extracted from

  • Mistry, D.; Stockley, R.A.
    IgA1 protease (2006), Int. J. Biochem. Cell Biol., 38, 1244-1248.
    View publication on PubMed

Application

Application Comment Organism
agriculture the beta domain of the IgA1 protease is able to transport alternative proteins to the protease domain of IgA1 protease as N terminal passenger proteins. This technology has been applied to immobilised heavy metals in soil Haemophilus influenzae
agriculture the beta domain of the IgA1 protease is able to transport alternative proteins to the protease domain of IgA1 protease as N terminal passenger proteins. This technology has been applied to immobilised heavy metals in soil Neisseria gonorrhoeae
agriculture the beta domain of the IgA1 protease is able to transport alternative proteins to the protease domain of IgA1 protease as N terminal passenger proteins. This technology has been applied to immobilised heavy metals in soil Neisseria meningitidis
agriculture the beta domain of the IgA1 protease is able to transport alternative proteins to the protease domain of IgA1 protease as N terminal passenger proteins. This technology has been applied to immobilised heavy metals in soil Streptococcus pneumoniae
drug development a fusion protein of the beta domain and a single-chain antibody to transmissible gastroenteritis coronavirus has been expressed on the surface of Escherichia coli. The single-chain antibody is then able to target and block the virus from infecting epithelial cells Haemophilus influenzae
drug development a fusion protein of the beta domain and a single-chain antibody to transmissible gastroenteritis coronavirus has been expressed on the surface of Escherichia coli. The single-chain antibody is then able to target and block the virus from infecting epithelial cells Neisseria gonorrhoeae
drug development a fusion protein of the beta domain and a single-chain antibody to transmissible gastroenteritis coronavirus has been expressed on the surface of Escherichia coli. The single-chain antibody is then able to target and block the virus from infecting epithelial cells Neisseria meningitidis
drug development a fusion protein of the beta domain and a single-chain antibody to transmissible gastroenteritis coronavirus has been expressed on the surface of Escherichia coli. The single-chain antibody is then able to target and block the virus from infecting epithelial cells Streptococcus pneumoniae
medicine inactivation of the enzyme has the potential to reduce bacterial colonisation at mucosal surrfaces Haemophilus influenzae
medicine inactivation of the enzyme has the potential to reduce bacterial colonisation at mucosal surrfaces Neisseria gonorrhoeae
medicine inactivation of the enzyme has the potential to reduce bacterial colonisation at mucosal surrfaces Neisseria meningitidis
medicine inactivation of the enzyme has the potential to reduce bacterial colonisation at mucosal surrfaces Streptococcus pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane
-
Haemophilus influenzae
-
-
cell membrane
-
Neisseria gonorrhoeae
-
-
cell membrane
-
Neisseria meningitidis
-
-
cell membrane
-
Streptococcus pneumoniae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IgA1 + H2O Haemophilus influenzae
-
?
-
?
IgA1 + H2O Neisseria gonorrhoeae
-
?
-
?
IgA1 + H2O Neisseria meningitidis
-
?
-
?
IgA1 + H2O Streptococcus pneumoniae
-
?
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IgA1 + H2O
-
Haemophilus influenzae ?
-
?
IgA1 + H2O
-
Neisseria gonorrhoeae ?
-
?
IgA1 + H2O
-
Neisseria meningitidis ?
-
?
IgA1 + H2O
-
Streptococcus pneumoniae ?
-
?
additional information in vitro studies show that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes Haemophilus influenzae ?
-
?
additional information in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes Neisseria gonorrhoeae ?
-
?
additional information in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes Neisseria meningitidis ?
-
?
additional information in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes Streptococcus pneumoniae ?
-
?

Synonyms

Synonyms Comment Organism
IgA1 protease
-
Haemophilus influenzae
IgA1 protease
-
Neisseria gonorrhoeae
IgA1 protease
-
Neisseria meningitidis
IgA1 protease
-
Streptococcus pneumoniae