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Literature summary for 3.4.21.71 extracted from
- Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B (2006), Pancreatology, 6, 224-231.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme needs to be proteolytically activated e.g. by trypsin, proelastase 2 is not activated by cathepsin B | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | pancreatic juice | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the enzyme needs to be proteolytically activated e.g. by trypsin, proelastase 2 is not activated by cathepsin B | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| proelastase 2 from pancreatic juice by anion and cation exchange chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic juice | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-succinyl-Ala-ALa-Pro-Leu-P-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Elastase 2 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | assay at | Homo sapiens |
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