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Literature summary for 3.4.21.7 extracted from

  • Robbins, K.C.; Summaria, L.
    Plasminogen and plasmin (1976), Methods Enzymol., 45, 257-273.
    View publication on PubMed
Search for more literature for 3.4.21.7

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25700
-
 x * 48800, A-chain, + x * 25700, B-chain, equilibrium sedimentation after cleavage of a single disulfide bond in Lys-plasminogen Homo sapiens
48800
-
 x * 48800, A-chain, + x * 25700, B-chain, equilibrium sedimentation after cleavage of a single disulfide bond in Lys-plasminogen Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation of plasminogen by cleavage of a sensitive Arg-Val peptide bond in the COOH-terminal portion of Glu-plasminogen to give the two-chain plasmin molecule, followed by the cleavage of a Lys-Lys peptide bond in the NH2-terminal portion of the molecule. The latter event results in the release of a peptide, or peptides Homo sapiens
proteolytic modification zymogen: plasminogen Homo sapiens
proteolytic modification zymogen: plasminogen Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin + H2O
-
 Homo sapiens ?
-
 ?
Fibrin + H2O
-
 Oryctolagus cuniculus ?
-
 ?
plasminogen + H2O
-
 Homo sapiens ?
-
 ?
plasminogen + H2O
-
 Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Oryctolagus cuniculus
monomer x * 48800, A-chain, + x * 25700, B-chain, equilibrium sedimentation after cleavage of a single disulfide bond in Lys-plasminogen Homo sapiens