Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | plasminogen is a major surface-bound protein | Homo sapiens | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
General Information | Comment | Organism |
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additional information | plasminogen is a major surface-bound protein interacting with pathogen Bacillus anthracis, it efficiently binds to spores of Bacillus anthracis in a lysine- and exosporium-dependent manner with alpha-enolase and elongation factor as specific receptors. Plasminogen-bound spores are capable of exhibiting anti-opsonic properties by cleaving C3b molecules in vitro and in rabbit bronchoalveolar lavage fluid, resulting in a decrease in macrophage phagocytosis. Mechanisms involved in the evasion of innate immunity by Bacillus anthracis through recruitment of plasminogen resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen, overview | Homo sapiens |