Literature summary for 3.4.21.7 extracted from

Li, Q.; Ke, F.; Zhang, W.; Shen, X.; Xu, Q.; Wang, H.; Yu, X.Z.; Leng, Q.; Wang, H.
Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice (2011), PLoS ONE, 6, e16483.

Search for more literature for 3.4.21.7

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha2-antiplasmin	contributes to the inactivation of plasmin activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	C57BL/6J mice, SCID mice, and BALB/c mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	purified enzyme	Homo sapiens	-
plasma	-	Homo sapiens	-
skin	-	Homo sapiens	-
skin	of the ears	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	contribution of plasmin to amplification of inflammation in patients with psoriasis. Annexin II, a receptor for plasmin is dramatically increased in both dermis and epidermis in psoriasis. Plasmin at sites of inflammation is pro-inflammatory, eliciting production of inflammatory factors, including CC chemokine ligand 20 and interleukin-23, that is mediated by the nuclear factor-kappaB (NF-kB) signaling pathway and that has an essential role in the recruitment and activation of pathogenic C-C chemokine receptor type 6+ T cells	Homo sapiens
physiological function	plasmin, converted from plasminogen by plasminogen activators, plays an essential role in amplification of psoriasiform skin inflammation in mice. Intradermal injection of plasmin or plasmin together with recombinant monocyte/macrophage chemotactic protein-1 results in induction of psoriasiform skin inflammation around the injection sites in mice. Histological analysis of skin sections from mice treated with plasmin and rMCP-1 reveal acanthosis, hyperorthokeratosis, subcorneal microabscesses, dilated lymphatic vessels and a diffuse inflammatory infiltrates in the dermis compared to normal epidermis and dermis in the ears of control mice. Plasmin triggers NF-kB-dependent IL-23 and CCL20 expression in macrophages	Mus musculus

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Release 2023.1 (January 2023)