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Literature summary for 3.4.21.7 extracted from

  • Martinez-Rizo, A.; Bueno-Topete, M.; Gonzalez-Cuevas, J.; Armendariz-Borunda, J.
    Plasmin plays a key role in the regulation of profibrogenic molecules in hepatic stellate cells (2010), Liver Int., 30, 298-310.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
Homo sapiens
Tranexamic acid a synthetic inhibitor efficiently decreasing plasmin activity, plasmin inhibition by tranexamic acid upregulates the profibrogenic genes, which respond to TGF-beta-intracellular signalling Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell
-
Homo sapiens
-
HSC-180 cell originally isolated from a cirrhotic liver Homo sapiens
-

General Information

General Information Comment Organism
malfunction plasmin inhibition by tranexamic acid upregulates the profibrogenic genes, which respond to TGF-beta-intracellular signalling Homo sapiens
additional information overexpression of human urokinase plasminogen activator in HSC 180 cells leads to increased plasmin activity, which is blocked by tranexamic acid in the transduced. Plasmin overexpression in the transduced cells significantly decreases gene expression of profibrogenic molecules, i.e. a1(I)collagen by 66%, TIMP-1 by 59%, alpha-smooth muscle actin by 90%, and TGF-beta by 55%. Both SnoN gene and protein expression increased prominently Homo sapiens
physiological function plasmin plays a key role in the regulation of profibrogenic molecules in hepatic stellate cells, role of plasmin in profibrogenic molecule expression, SnoN transcriptional kinetics and gelatinase activation Homo sapiens