Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.7 extracted from

  • Kothari, H.; Kaur, G.; Sahoo, S.; Idell, S.; Rao, L.V.; Pendurthi, U.
    Plasmin enhances cell surface tissue factor activity in mesothelial and endothelial cells (2009), J. Thromb. Haemost., 7, 121-131.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.7

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens both plasmin and thrombin increase cell surface tissue factor activity in human pleural mesothelial cells by 3- to 4fold. Plasmin-induced tissue factor activity is not dependent on the de novo synthesis of tissue factor. In HUVEC, plasmin has a minimal effect on unperturbed HUVEC whereas it markedly increases tissue factor activity of activated HUVEC. Plasmin treatment neither affects anionic phospholipid levels at the cell surface nor releases protein disulfide isomerase ?
-
 ?
tissue factor pathway inhibitor + H2O Homo sapiens plasmin increases tissue factor activity by inactivating the cell-associated tissue factor pathway inhibitor by a limited proteolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information both plasmin and thrombin increase cell surface tissue factor activity in human pleural mesothelial cells by 3- to 4fold. Plasmin-induced tissue factor activity is not dependent on the de novo synthesis of tissue factor. In HUVEC, plasmin has a minimal effect on unperturbed HUVEC whereas it markedly increases tissue factor activity of activated HUVEC. Plasmin treatment neither affects anionic phospholipid levels at the cell surface nor releases protein disulfide isomerase Homo sapiens ?
-
 ?
tissue factor pathway inhibitor + H2O plasmin increases tissue factor activity by inactivating the cell-associated tissue factor pathway inhibitor by a limited proteolysis Homo sapiens ?
-
 ?