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Literature summary for 3.4.21.7 extracted from

  • Kucharewicz, I.; Mogielnicki, A.; Kasacka, I.; Buczko, W.; Bodzenta-?ukaszyk, A.
    Plasmin system regulation in an ovalbumin-induced rat model of asthma (2008), Int. Arch. Allergy Immunol., 147, 190-196.
    View publication on PubMed

Application

Application Comment Organism
medicine induction of asthma by ovalbumin results in thickening of the airway wall, hypertrophy of smooth muscle cells, infiltration of inflammatory cells, subepithelial fibrosis, epithelial and endothelial lesions. Tissue plasminogen activator activity is significantly decreased in asthmatic animals, and activity of plasmin inhibitor PAI-1 is significantly higher as is alpha2-antiplasmin, consistent with the superiority of plasmin system inhibition over activation in plasma Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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ovalbumin-induced rat model of asthma
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