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Literature summary for 3.4.21.7 extracted from

  • Huang, Y.; Border, W.A.; Lawrence, D.A.; Noble, N.A.
    Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis (2006), Kidney Int., 70, 515-522.
    View publication on PubMed
Search for more literature for 3.4.21.7

Application

Application Comment Organism
medicine a mutant, noninhibitory plasminogen activator inhibitor-type 1 reduces pathological ECM accumulation in anti-thy-1 nephritis, in large part through effectively competing with native plasminogen activator inhibitor-type 1, thereby restoring plasmin generation and increasing plasmin-dependent degradation of matrix components Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha2-antiplasmin plasmin inhibitor, completely blocks ability of noninhibitory plasminogen activator inhibitor-type 1 to normalize ECM degradation Rattus norvegicus
Aprotinin plasmin inhibitor, completely blocks ability of noninhibitory plasminogen activator inhibitor-type 1 to normalize ECM degradation Rattus norvegicus
additional information noninhibitory plasminogen activator inhibitor-type 1 has no effect on plasmin activity and degradation of casein Rattus norvegicus
plasminogen activator inhibitor-type 1 totally blocks plasmin activity and degradation of casein Rattus norvegicus
Tranexamic acid plasmin inhibitor, completely blocks ability of noninhibitory plasminogen activator inhibitor-type 1 to normalize ECM degradation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mesangial cell
-
 Rattus norvegicus
-
additional information ECM Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Rattus norvegicus ?
-
 ?
chromozyme PL + H2O
-
 Rattus norvegicus ?
-
 ?