Application | Comment | Organism |
---|---|---|
medicine | plasmin generated in atherosclerotic lesion can induce macrophage activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG490 | JAK inhibitor, inhibits JAK1 but does not inhibit TYK2 phosphorylation by plasmin. Impairs plasmin-mediated phosphorylation of ERK1/2, Akt1, and the subsequent phosphorylation of IkappaBalpha, but not that of p38 MAPK. Inhibits plasmin-induced TNF-alpha release by 63% and IL-6 release by 76% | Homo sapiens | |
AKbetaBA | inhibits plasmin-induced TNF-alpha release by 70%. Inhibits plasmin-induced activation of NF-kappaB by 66% | Homo sapiens | |
additional information | inhibition of ERK1/2 by MEK inhibitor U0126 does not affect plasmin-mediated expression of TNF-alpha | Homo sapiens | |
SB203580 | inhibits plasmin-induced TNF-alpha release by 75% and IL-6 release by 79% | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | plasmin triggers expression and release of proinflammatory cytokines such as TNF-alpha and IL-6 in human monocyte-derived macrophages with a somewhat lower potency than the standard stimulus lipopolysaccharide. Plasmin-induced activation of JAK1, p38, ERK1/2, and NF-kappaB is indispensable for the cytokine expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
annexin A2 + H2O | stimulation of macrophages with plasmin leads to cleavage of ca. 6% of annexin A2 yielding a proteolytic fragment of ca. 33 kDa | Homo sapiens | ? | - |
? | |
ERK1/2 | triggers activation | Homo sapiens | ? | - |
? | |
IkappaBalpha | plasmin induces phosphorylation of IkappaBalpha, targeting the inhibitor to proteosomal degradation, consequently allowing nuclear translocation of NF-kappaB | Homo sapiens | ? | - |
? | |
JAK1 | triggers tyrosine phosphorylation | Homo sapiens | ? | - |
? | |
additional information | plasmin does not induce phosphorylation of JAK2 or JAK3. Does not activate SAP/JNK. Does not trigger activation and nuclear translocation ofSTAT1, STAT5A, or STAT5B | Homo sapiens | ? | - |
? | |
p38 MAPK | triggers phosphorylation | Homo sapiens | ? | - |
? | |
p65 | triggeres nuclear translocation | Homo sapiens | ? | - |
? | |
STAT3 | phosphorylates on Tyr705 and Ser727. Triggeres activation and nuclear translocation of STAT3 | Homo sapiens | ? | - |
? | |
TYK2 | triggers tyrosine phosphorylation | Homo sapiens | ? | - |
? |