Literature summary for 3.4.21.7 extracted from

Tucker, H.M.; Kihiko, M.; Caldwell, J.N.; Wright, S.; Kawarabayashi, T.; Price, D.; Walker, D.; Scheff, S.; McGillis, J.P.; Rydel, R.E.; Estus, S.
The plasmin system is induced by and degrades amyloid-beta aggregates (2000), J. Neurosci., 20, 3937-3946.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid-beta + H2O	Homo sapiens	the plasmin pathway is induced by aggregated amyloid-beta, which can lead to amyloid-beta degradation and inhibition of amyloid-beta actions	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid-beta + H2O	plasmin cleaves at multiple sites	Homo sapiens	?	-	?
amyloid-beta + H2O	the plasmin pathway is induced by aggregated amyloid-beta, which can lead to amyloid-beta degradation and inhibition of amyloid-beta actions	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)