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Literature summary for 3.4.21.69 extracted from

  • Keller, S.A.; Moore, C.C.; Clemens, M.G.; McKillop, I.H.; Huynh, T.
    Activated protein C restores hepatic microcirculation during sepsis by modulating vasoregulator expression (2011), Shock, 36, 361-369.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
Activated protein C
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Homo sapiens
APC
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Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C promotes fibrinolysis while inhibiting coagulation and inflammation. Although aPC does not affect ET-1-dependent sinusoidal vasoconstriction, it induces hepatoprotective effects via enhanced red blood cell velocity. aPC ameliorates ET-1-dependent changes in hepatic microcirculation and improves hepatic function in the setting of sepsis in rats Homo sapiens