Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.69 extracted from

  • Stephenson, D.A.; Toltl, L.J.; Beaudin, S.; Liaw, P.C.
    Modulation of monocyte function by activated protein C, a natural anticoagulant (2006), J. Immunol., 177, 2115-2122.
    View publication on PubMed
Search for more literature for 3.4.21.69

Activating Compound

Activating Compound Comment Organism Structure
additional information the antiapoptotic effect of activated protein C requires its serine protease domain and is dependent on the endothelial cell protein C receptor and protease-activated receptor-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activated protein C is a physiological anticoagulant, it also exerts anti-inflammatory and antiapoptotic effects, activated protein C inhibits the production of TNF, IL-1beta, IL-6, and IL-8 and inhibits camptothecin-induced apoptosis in a dose-dependent manner in the LPS-stimulated immortalized human monocytic cell line THP-1, activated protein C inhibited spontaneous apoptosis in primary blood monocytes from healthy individuals, activated protein C does not influence the phagocytic internalization of Gram-negative and Gram-positive bioparticles by THP-1 cells or by primary blood monocytes, it does not affect the expression of adhesion molecules by LPS-stimulated blood monocytes nor the ability of monocytes to adhere to LPS-stimulated endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
monocyte primary blood monocytes Homo sapiens
-
THP-1 cell an immortalized human monocytic cell line Homo sapiens
-
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activated protein C is a physiological anticoagulant, it also exerts anti-inflammatory and antiapoptotic effects, activated protein C inhibits the production of TNF, IL-1beta, IL-6, and IL-8 and inhibits camptothecin-induced apoptosis in a dose-dependent manner in the LPS-stimulated immortalized human monocytic cell line THP-1, activated protein C inhibited spontaneous apoptosis in primary blood monocytes from healthy individuals, activated protein C does not influence the phagocytic internalization of Gram-negative and Gram-positive bioparticles by THP-1 cells or by primary blood monocytes, it does not affect the expression of adhesion molecules by LPS-stimulated blood monocytes nor the ability of monocytes to adhere to LPS-stimulated endothelial cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
APC
-
 Homo sapiens