Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipids | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics with wild-type and mutant factor VIIIa substrates | Homo sapiens | |
0.0001 | - |
Factor VIIIa | pH 7.2, 37°C, activated protein C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor VIIIa + H2O | Homo sapiens | proteolytic inactivation | inactive factor VIII + domain B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity with wild-type and mutant factor VIIIa substrates at cleavage site Arg336 and Arg562 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor VIIIa + H2O | proteolytic inactivation | Homo sapiens | inactive factor VIII + domain B | - |
? | |
active factor VIIIa + H2O | proteolytic inactivation with cleavage at Arg336 within the factor VIIIa A1 subunit and Arg562 within the A2 subunit, reduced activity with three 336(P4-P3')562 fator VIII variants, possessing mutations surrounding Arg336, compared to wild-type fVIIIa, the rate of cleavage for the A1 subunit of the fully substituted P4-P3' mutant is reduced by 100fold relative to wild-type, cleavage of the A2 subunit for the 336(P4-P3')562 appear a few fold slower than that for wild-type, overview | Homo sapiens | inactive factor VIII + domain B | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |