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Literature summary for 3.4.21.69 extracted from

  • Qureshi, S.H.; Manithody, C.; Bae, J.S.; Yang, L.; Rezaie, A.R.
    Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays (2008), Biophys. Chem., 134, 239-245.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information substitution of the autolysis loop of APC with the corresponding loop of trypsin has no influence on the proteolytic activity of the protease towards factor Va, however, this substitution increases the reactivity of APC with plasma inhibitors so that the mutant exhibits no anticoagulant activity in plasma, the mutant APC cannot interact with protein S as cofactor, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
active factor Va + H2O Homo sapiens proteolytic inactivation inactive factor V + ?
-
 ?
protease activated receptor 1 + H2O Homo sapiens APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, thereby eliciting antiinflammatory and cytoprotective signaling responses in endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + ?
-
 ?
active factor Va + H2O proteolytic inactivation, the autolysis loop of APC represents the active site, active site topology, the loop plays a critical role in restricting both the specificity and spatial environment of the active-site groove of APC, overview Homo sapiens inactive factor V + ?
-
 ?
protease activated receptor 1 + H2O APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, thereby eliciting antiinflammatory and cytoprotective signaling responses in endothelial cells Homo sapiens ?
-
 ?
protease activated receptor 1 + H2O APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, APC cleaves the PAR-1 exodomain with about 750fold lower catalytic efficiency than thrombin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
APC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
protein S from human plasma, interacts with the autolysis loop of the enzyme Homo sapiens