Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipid | accelerates cleavages at Arg506, Arg679 and Arg306 to a different extent | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
membrane-bound factor Va | - |
Homo sapiens | |
0.000196 | - |
Factor VaR506Q | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | in the membrane-bound factor Va cleavage occurs rapidly at Arg506 and is followed by a slower proteolysis at Arg306 and a final, very slow cleavage at Arg679 | Homo sapiens | ? | - |
? | |
Factor VaR506Q + H2O | The substrate is derived from factor Va by replacing Arg506 by Gln. In the presence of phospholipids the substrate is hydrolyzed at Arg306, but in the absence of phospholipids hydrolysis occurs at Arg679, followed by cleavage at Arg306, suggesting that the binding of phospholipids alters the accessibility of Arg679 | Homo sapiens | ? | - |
? | |
Factor VaR506Q + H2O | cleavage of Arg306 in factor VaR506Q | Homo sapiens | ? | - |
? | |
membrane-bound factor Va + H2O | cleavage of Arg506 in membrane-bound factor Va | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.37 | - |
Factor VaR506Q | - |
Homo sapiens | |
0.96 | - |
membrane-bound factor Va | - |
Homo sapiens |