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Literature summary for 3.4.21.69 extracted from
- Protein C (1981), Methods Enzymol., 80, 320-332.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Benzamidine hydrochloride | - |
Bos taurus |  |
| Benzamidine hydrochloride | - |
Homo sapiens | |
| diisopropyl fluorophosphate | - |
Bos taurus | |
| diisopropyl fluorophosphate | - |
Homo sapiens | |
| phenylmethylsulfonyl fluoride | - |
Bos taurus | |
| phenylmethylsulfonyl fluoride | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca | Bos taurus |
| 41000 | - |
1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca | Bos taurus |
| 54300 | - |
bovine, protein C, amino acid and carbohydrate composition data, conversion to protein Ca by hydrolysis of a specific peptide bond in the amino-terminal region of the heavy chain between Arg14 and Ile15, giving rise to protein Ca, MW 52650 and an activation peptide, MW 1650 | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | bovine protein C contains 14% carbohydrate, approximately 15 residues of hexose, 12 residues of hexosamine and 9 residues of sialic acid distributed in 3 carbohydrate chains, human protein C contains 23% carbohydrate, approximately 14 residues of galactose, 21 residues of mannose, 23 residues of glucosamine and 12 residues of sialic acid | Homo sapiens |
| glycoprotein | bovine protein C contains 14% carbohydrate, approximately 15 residues of hexose, 12 residues of hexosamine and 9 residues of sialic acid distributed in 3 carbohydrate chains, human protein C contains 23% carbohydrate, approximately 14 residues of galactose, 21 residues of mannose, 23 residues of glucosamine and 12 residues of sialic acid | Bos taurus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
| plasma | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor Va + H2O | - |
Homo sapiens | ? | - |
? | |
| Factor Va + H2O | - |
Bos taurus | ? | - |
? | |
| Factor VIIIa + H2O | - |
Homo sapiens | ? | - |
? | |
| Factor VIIIa + H2O | - |
Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 41000 + 1 * 21000, bovine protein C, SDS-PAGE of reduced protein, heavy and light chain are connected by a disulfide bond, cleavage of Arg12-Leu13 in the heavy chain releases a small activation peptide, MW 1400 and protein Ca | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin K | enzyme is dependent on | Homo sapiens | |
| vitamin K | enzyme is dependent on | Bos taurus | |
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Release 2023.1 (January 2023)
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