Literature summary for 3.4.21.68 extracted from

Abdoli Nasab, M.; Jalali Javaran, M.; Cusido, R.M.; Palazon, J.
Purification of recombinant tissue plasminogen activator (rtPA) protein from transplastomic tobacco plants (2016), Plant Physiol. Biochem., 108, 139-144 .

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Cloned(Commentary)

Cloned (Comment)	Organism
construction of plastid transformation vector pKCZK2S for expressing the K2S gene in Nicotiana tabacum chloroplast genome under the control of the constitutive Prrn promoter, and the 3' UTR of the Chlamydomonas rbcl gene as a terminator, recombinant expression of His6-tagged truncated form of the tissue plasminogen activator, K2S, in Nicotiana tabacum leaf chloroplasts	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a truncated form of the tissue plasminogen activator, K2S, which has a longer plasma half-life, better diffusion into the clot, and higher fibrinolytic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00750	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant His6-tagged truncated enzyme form K2S from Nicotiana tabacum chloroplasts by nickel affinity chromatography and dialysis, the His-tag is cleaved off by protease factor Xa	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Tissue plasminogen activator	-	Homo sapiens
tPA	-	Homo sapiens

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Release 2023.1 (January 2023)