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Literature summary for 3.4.21.68 extracted from
- Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator (2011), PLoS ONE, 6, e25919.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| plasminogen activator inhibitor-1 | PAI-1, endogenous inhibitor of tPA in the cell | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| neuronal cell | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue-type plasminogen activator | - |
Rattus norvegicus |
| tPA | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tPA is a pivotal player in slowly progressing activity deprivation-induced neurodegeneration, e.g. induced by blockade of neuronal activity using tetrodotoxin, TTX. Neurons degenerate slowly and die in a manner resembling neurodegenerative diseases-induced neuronal cell death. Transfection of an endogenous tPA inhibitor, plasminogen activator inhibitor-1, protected the TTX-exposed neurons from dying | Rattus norvegicus |
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