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Literature summary for 3.4.21.68 extracted from

  • Sashindranath, M.; Samson, A.L.; Downes, C.E.; Crack, P.J.; Lawrence, A.J.; Li, Q.X.; Ng, A.Q.; Jones, N.C.; Farrugia, J.J.; Abdella, E.; Vassalli, J.D.; Madani, R.; Medcalf, R.L.
    Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation (2011), Lab. Invest., 91, 1079-1091.
    View publication on PubMed
Search for more literature for 3.4.21.68

Application

Application Comment Organism
diagnostics alterations in tPA activity levels can be used as a biomarker for perturbations in brain homeostasis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of tPA knockout mice, and of transgenic T4 mice selectively overexpressing tPA in neurons Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
plasminogen + H2O Mus musculus C57/BL6J
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Mus musculus
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brain
-
 Mus musculus
-
central nervous system tissue-type plasminogen activator is a major protease of the central nervous system Mus musculus
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cerebellum
-
 Mus musculus
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cerebral cortex
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
additional information real-time PCR quantitative mRNA analysis and activity distribution in control and stimulated brain sections, overview Mus musculus
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neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the amidolytic assay can be adapted to accurately detect changes in net tPA activity in mouse brain tissues, examination of differences in net tPA activity in the cerebral cortex, sub-cortical structures and cerebellum in wild-type and tPA knockout mice, and in transgenic T4 mice selectively overexpressing tPA in neurons, overview Mus musculus ?
-
 ?
additional information the amidolytic assay can be adapted to accurately detect changes in net tPA activity in mouse brain tissues, examination of differences in net tPA activity in the cerebral cortex, sub-cortical structures and cerebellum in wild-type and tPA knockout mice, and in transgenic T4 mice selectively overexpressing tPA in neurons, overview Mus musculus C57/BL6J ?
-
 ?
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
plasminogen + H2O in situ zymography assay Mus musculus plasmin + ?
-
 ?
plasminogen + H2O
-
 Mus musculus C57/BL6J plasmin + ?
-
 ?
plasminogen + H2O in situ zymography assay Mus musculus C57/BL6J plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue-type plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
malfunction altered tPA activity levels in mouse models of Alzheimer's disease and spinocerebellar ataxia type-1, SCA1. Decreased tPA activity is detected in the cortex and subcortex of Alzheimer's disease mice, whereas increased tPA activity is found in the cerebellum of SCA1 mice Mus musculus
physiological function tPA is an initiator of intravascular fibrinolysis and is a complex mediator of brain function and dysfunction. tPA participates in various forms of chronic neurodegeneration, and plays a functional role following morphine administration, epileptic seizures, traumatic brain injury and ischaemic stroke-neurological settings Mus musculus