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Literature summary for 3.4.21.68 extracted from
- Endothelial progenitor populations in differentiating embryonic stem cells. II. Drug selection and functional characterization (2010), Tissue Eng. Part A, 16, 1065-1074.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| plasminogen activator inhibitor-1 | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryonic stem cell line | - |
Mus musculus | - |
| EOMA cell | mouse endothelial cell line EOMA | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue plasminogen activator | - |
Mus musculus |
| tPA | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | for hemostatic function of endothelial cells, tissue plasminogen activator secretion by Puro-selected endothelial cells are measured with or without shear stress exposure. Tissue plasminogen activator, which has fibrinolytic function, is known to increase with exposure to shear stress. Free tissue plasminogen activator level is increased in Tie1- and platelet endothelial cell adhesion molecule promoter-driven Puro-selected cells, but Flk1 and vascular endothelial-cadherin promoter-driven cells show the opposite trend. The levels of free tissue plasminogen activator in embryonic stem cell-derived cells are much higher than that of EOMA cells in general. plasminogen activator inhibitor-1 secretion by these cells can be estimated by comparing the ratio between free and total tissue plasminogen activator because total tissue plasminogen activator reflects plasminogen activator inhibitor-1 bound as well as free tissue plasminogen activator. Abnormally high plasminogen activator inhibitor-1 secretion indicates by high bound tissue plasminogen activator in EOMA cells can result from in vitro culture conditions of EOMA in its proliferative state, because quiescent endothelial cells have very low plasminogen activator inhibitor-1. Higher free/total tissue plasminogen activator ratio in embryonic stem cell-derived endothelial cells indicates lower plasminogen activator inhibitor-1 level in these cells, and thus these cells may be closer to quiescence | additional information |
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