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Literature summary for 3.4.21.68 extracted from

  • Lapchak, P.A.; Han, M.K.
    Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor, but not the thrombolytic tissue plasminogen activator (2010), Brain Res., 1344, 217-225.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in the rabbit small clot embolic stroke model, which is a useful translational model and possibly a predictor of treatments that may show efficacy in human clinical trials, in combination with the thrombolytic, tissue plasminogen activator using a standard intravenous dose of 3.3 mg/kg (20% bolus, 80% infused), simvastatin can be safely administered with tissue plasminogen activator to improve clinical scores Oryctolagus cuniculus
medicine tissue plasminogen activator is the first-line treatment for stroke patients Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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-
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Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
Oryctolagus cuniculus
tPA
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Oryctolagus cuniculus