Literature summary for 3.4.21.68 extracted from

Robb, A.O.; Mills, N.L.; Din, J.N.; Cameron, S.; Ludlam, C.A.; Newby, D.E.; Denison, F.C.
Acute endothelial tissue plasminogen activator release in pregnancy (2009), J. Thromb. Haemost., 7, 138-142.

Search for more literature for 3.4.21.68

Activating Compound

Activating Compound	Comment	Organism	Structure
bradykinin	endothelium-dependent vasodilator that stimulates the release of t-PA. Causes a dose-dependent increase in plasma t-PA antigen and activity concentrations in the infused arm of both pregnant and non-pregnant women. The increase in t-PA activity is greater in the nonpregnant women. Bradykinin increases the net release of t-PA antigen and activity in both pregnant women and non-pregnant women. Both net release of active t-PA and plasma t-PA/plasminogen activator inhibitor type 1 ratios are markedly reduced in pregnant women	Homo sapiens
additional information	nitroprusside, which is an endothelium-independent vasodilator, does not stimulate release of t-PA	Homo sapiens

Application

Application	Comment	Organism
medicine	pregnancy is associated with major perturbations of endogenous fibrinolytic capacity with an overwhelming increase in plasma plasminogen activator inhibitor type 1 concentrations and an inadequate release of active t-PA, i.e., these prothrombotic effects may, in part, explain the increased risk of arterial and venous thrombosis in pregnant women	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
plasminogen activator inhibitor type 1	pregnant women have higher plasma plasminogen activator inhibitor type 1 antigen concentrations that result in lower basal t-PA/plasminogen activator inhibitor type 1 ratios and plasma t-PA activity concentrations	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	-	Homo sapiens	-
plasma	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
t-PA	-	Homo sapiens
Tissue plasminogen activator	-	Homo sapiens

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Release 2023.1 (January 2023)