Application | Comment | Organism |
---|---|---|
drug development | antifibrinolytic agents may be useful for protecting neurons when tPA-mediated damage is anticipated | synthetic construct |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | mitigates tPA-induced neuronal injury. Pre-treatment of N27 cells with aprotinin for 30 min before tPA exposure is protective against cell death, increasing the cell viability to 91.8% at a tPA concentration of 20 microg/ml. When aprotinin treatment follows tPA exposure, cell death is proportional to the length of tPA exposure | synthetic construct | |
bivalirudin | does not exert any protective effect when added at concentrations of 20-200 microg/ml (cell viability of 51.8%) | synthetic construct | |
epsilon-aminocaproic acid | mitigates tPA-induced neuronal injury | synthetic construct | |
Glu-Gly-Arg-chlormethylketone | directly binds to the catalytic site of tPA. 100 microg/ml given before tPA exposure, reduces cell death (cell viability of 80.5%) | synthetic construct | |
Phe-Pro-Arg-chlormethylketone | directly binds to the catalytic site of tPA. 100 microg/ml given before tPA exposure, reduces cell death (cell viability of 85.7%) | synthetic construct |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
synthetic construct | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | tPA induces N27 neuroblast cell death in a dose-and time-dependent manner | synthetic construct | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
synthetic construct |
tPA | - |
synthetic construct |