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Literature summary for 3.4.21.68 extracted from

  • Davis-Jackson, R.; Correa, H.; Horswell, R.; Sadowska-Krowicka, H.; McDonough, K.; Debata, C.; Gardner, R.; Penn, D.
    Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig (2006), Thromb. J., 4, 7.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine combining antithrombin III, R-TPA and supportive care is more advantageous in treating the clinical manifestations of disseminated intravascular coagulation in this neonatal pig model than either single modality or supportive care alone Sus scrofa

Protein Variants

Protein Variants Comment Organism
additional information disseminated intravascular coagulation is induced in 27 neonatal pigs (7 to 14 days of age) by intravenous administration of Escherichia coli endotoxin (800 microgram/kg over 30 min). Pigletes are treated with A: supportive care alone, B: antithrombin III (50 microgram/kg bolus, 25 microgram/kg per h continuous infusion) and supportive care, C: recombinant tissue plasminogen activator (R-TPA, 25 mcrogram/kg per h continuous infusion) and supportive care; D: antithrombin III, R-TPA and supportive care. Compared with supportive care alone, combination therapy with antithrombin III and R-TPA results in a significant improvement of survival time, hematocrit, antithrombin III level, macroscopic and microscopic organ involvement. Compared with supportive care alone, R-TPA alone significantly reduces macroscopic organ involvement Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
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-
-

Synonyms

Synonyms Comment Organism
r-tPA
-
 Sus scrofa
recombinant tissue plasminogen activator
-
 Sus scrofa