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Literature summary for 3.4.21.68 extracted from

  • Cacquevel, M.; Launay, S.; Castel, H.; Benchenane, K.; Cheenne, S.; Buee, L.; Moons, L.; Delacourte, A.; Carmeliet, P.; Vivien, D.
    Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms (2007), Neurobiol. Dis., 27, 164-173.
    View publication on PubMed
Search for more literature for 3.4.21.68

Application

Application Comment Organism
medicine the present data support a model in which amyloid deposition in Alzheimer's disease induces a decrease in tPA activity through the overproduction of PAI-1 by activated glial cells Mus musculus
medicine the present data support a model in which amyloid deposition in Alzheimer's disease induces a decrease in tPA activity through the overproduction of PAI-1 by activated glial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor type 1 (PAI-1)
-
 Homo sapiens
plasminogen activator inhibitor type 1 (PAI-1)
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain a decreased expression on the protein and on the mRNA level in elderly mice and in mice overproducing amyloid-beta peptide assemblies is shown Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 a study in sporadic Alzheimer's disease and age-matched control brain tissues reveals that the tPA proteolytic activity is negatively correlated to amyloid-beta peptide levels Homo sapiens
additional information
-
 cerebral tPA activity is decreased during ageing in normal mice and this effect is worsened in mice overproducing amyloid-beta peptide assemblies. These phenomena result from a decrease in tPA expression and from an increase in the production of one of the tPA inhibitors, the plasminogen activator inhibitor type 1 (PAI-1) Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
tPA
-
 Mus musculus
tPA
-
 Homo sapiens