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Literature summary for 3.4.21.68 extracted from

  • Lee, S.B.; Oh, H.K.; Kim, H.K.; Joe, Y.A.
    Expression of the non-glycosylated kringle domain of tissue type plasminogen activator in Pichia and its anti-endothelial cell activity (2006), Protein Expr. Purif., 50, 1-8.
    View publication on PubMed

Application

Application Comment Organism
medicine non-glycosylated TK1-2 useful for the treatment of cancer can be efficiently produced in Pichia, with retaining its activity Komagataella pastoris

Protein Variants

Protein Variants Comment Organism
N117Q/N184Q results in a non-glycosylated protein, inhibits endothelial cell proliferation and migration stimulated by bFGF and VEGF, respectively Komagataella pastoris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19950
-
two-kringle domain mutant N117Q/N184Q, monomer, mass spectroscopy Komagataella pastoris
20000
-
two-kringle domain mutant N117Q/N184Q, monomer, SDS-PAGE Komagataella pastoris

Organism

Organism UniProt Comment Textmining
Komagataella pastoris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
mutant N117Q/N184Q Komagataella pastoris

Synonyms

Synonyms Comment Organism
tissue type plasminogen activator
-
Komagataella pastoris